Health Canada approves skin health claims for SynbÆctive ProBeautyShield | Nutritional Outlook

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The patented probiotic complex SynbÆctive ProBeautyShield was granted a Product License by Health Canada, validating several skin health claims for its beauty from within properties, SynBalance SRL announced.1 The complex supports skin health through the gut-skin axis support, utilizing a blend of L. plantarum PBS067, L. rhamnosus LRH020, and L. reuteri PBS072 to help modulate the immune system and promote antimicrobial properties against pathogens.

Clinical evidence: probiotics for acne, eczema, and skin aging

The selection of the bacterial strains in SynbÆctive ProBeautyShield was based on published evidence demonstrating their effects.2 Additionally, several trials demonstrated the complex’s effects on acne, atopic dermatitis, and skin aging.

In the recently published double-blind randomized placebo-controlled clinical trial, “Investigating the impact of oral probiotic supplementation for acne management: A randomized controlled trial,” 64 adult female participants received the one capsule per day of the probiotic supplementation, or a placebo, for 54 days.3 The supplementation supported skin hydration, improved sebum and pH, and decreased lesions, compared to placebo.

The probiotic complex also demonstrated benefits for atopic dermatitis. In the 2021 study, “Efficacy of a probiotic supplement in patients with atopic dermatitis: a randomized, double-blind, placebo-controlled clinical trial,” 80 adult participants with mild-to-severe atopic dermatitis received either the probiotic supplement or a placebo for 56 days.4 Evaluations demonstrated an increase in skin smoothness, skin moisturization, and self-perception with the probiotic, as well as a decrease in the levels of inflammatory markers.

The 2025 study, “Skin Antiaging and Skin Health Benefits of Probiotic Intake Combined with Topical Ectoin and Sodium Hyaluronate: A Randomized, Double-Blind, Placebo-Controlled Trial,” showed improvements in the appearance of skin aging associated with an improvement in the skin microbiome.5 In this study, 96 participants were given the probiotic complex or a placebo for 8 weeks. Improvements in wrinkle depth, skin hydration, and skin radiance were measured in the probiotic group.

Health Canada–approved skin health claims for SynbÆctive ProBeautyShield

As explained in the September 30 press release, the gut-skin axis can support skin health with a hydrated and healthier complexion, reduce appearance of skin aging, and affect conditions such as acne and atopic dermatitis.

SynbÆctive ProBeautyShield is now authorized to make these skin health claims:

  • Help relieve symptoms such as skin tightness, dryness, itching, and burning in mild to moderate cases of atopic dermatitis (eczema).
  • Helps improve symptoms such as skin tightness, dryness, itching, and burning associated with mild to moderate atopic dermatitis (eczema).
  • Helps to improve symptoms such as skin roughness associated with atopic dermatitis (eczema).
  • Helps provide relief from symptoms such as skin tightness, dryness, itching, and burning associated with atopic dermatitis,
  • Clinically shown to help reduce symptoms such as skin tightness, dryness, itching, and burning associated with atopic dermatitis.
  • Source of probiotics to help support skin health in people with atopic dermatitis,
  • Helps to support skin moisture and smoothness in those with mild atopic dermatitis
  • Helps to support skin hydration and smoothness in those with mild atopic dermatitis

Market potential and beauty-from-within applications

The new approval from Health Canada enables market opportunities and clinical credibility in North American industry. SynBalanced SRL worked in collaboration with their Canadian partner Prebionature, with the aim of bringing SynBalance to local and international brands.

“We are thrilled that an institution as rigorous as Health Canada has recognized the quality and scientific value of ProBeautyShield” stated Cristiana Piangiolino, managing director of SynBalance SRL, in the press release. “This achievement reflects our dedication to developing innovative, science-backed probiotic ingredients. We also want to extend our gratitude to our partner Prebionature for their invaluable support throughout this journey.”

The complex was also named a finalist at the NutraIngredients Asia Awards 2025 in the Ingredient of the Year: Beauty from Within category.

References

  1. SynBalance. Health Canada Authorizes Functional Claims for SynbÆctive® ProBeautyShield, an Innovative Probiotic Complex for Skin Health. September 30, 2025. (accessed 2025-09-30).
  2. Presti, I., D’Orazio, G., Labra, M. et al. Evaluation of the probiotic properties of new Lactobacillus and Bifidobacterium strains and their in vitro effect. Appl Microbiol Biotechnol. 2025. 99, 5613–5626. DOI: 10.1007/s00253-015-6482-8
  3. Shi, Z.; Malfa, P.; De Ponti, I.; Yu, X.; Squarzanti, DF.; Lo Re, M.; Tursi, F. Investigating the impact of oral probiotic supplementation for acne management: A randomized controlled trial. Our Dermatol Online. 2024, 15(3), 210-219. DOI: 10.7241/ourd.20243.1
  4. Michelotti, A.; Cestone, E.; De Ponti, I.; Giardina, S.; Pisati, M.; Spartà, E.; Tursi, F. Efficacy of a probiotic supplement in patients with atopic dermatitis: a randomized, double-blind, placebo-controlled clinical trial. Eur J Dermatol. 2021, 31(2), 225-232. DOI: 10.1684/ejd.2021.4019
  5. Nobile, V.; Hajat, C.; Cestone, E.; Cascella, F.; Santus, G. Skin Antiaging and Skin Health Benefits of Probiotic Intake Combined with Topical Ectoin and Sodium Hyaluronate: A Randomized, Double-Blind, Placebo-Controlled Trial. Cosmetics. 2025, 12(2), 34. DOI: 10.3390/cosmetics12020034